A 59 year old male was delivered to our stroke unit in the Xuanwu hospital three hours after onset of right-sided extremity weakness and a right-sided hemiparesis. On examination in the emergency room, he was found to have profound right extremity paresis, an expressive aphasia and facial palsy on the right side. A complete stroke evaluation was scheduled. In order to meet the demand of fast hemodynamic imaging of the entire brain, CT Perfusion and whole brain perfused blood volume calculation using syngo Neuro PBV (Perfused Blood Volume)* were performed. This new approach allows for routine calculation of three-dimensional, color-coded whole brain images overcoming the limited scan coverage of Perfusion CT.