Chest pain with exertion


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Abstract:  21-year-old male presents complaining of persistent chest pain on exertion.
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Diagnosis

Partial congenital absence of pericardium (left-sided).

Findings

There is leftward shift of the cardiac silhouette secondary to the pericardial defect and a mild pectus deformity. The aorto-pulmonary window forms an acute angle filled with lung tissue (rather than pericardium). The pulmonary outflow tract is prominent superiorly. Lucency at the base of the heart represents interposed lung between the heart and diaphragm in absence of the pericardium. The pulmonary vasculature is prominent.

Discussion

Congenital absence of the pericardium is estimated to occur in 1 in 13,000 persons with a male to female ratio of 3:1. It may be detected at any age with average age of detection at 21 years. The entire pericardium or only a portion may be absent. Partial defects are the most common and occur over the left atrial appendage most commonly. Diaphragmatic, right atrial and SVC pericardial defects are less common. Entire absence of the pericardium is rare. Multiple cardiac and mediastinal abnormalities are associated with this condition including ASD, PDA, tetralogy of Fallot, bronchogenic cysts, diaphragmatic hernia, mitral stenosis and pulmonary sequestration. Partial absence places patients at risk of herniation through the defect with strangulation of cardiac tissue (classically the left atrial appendage). Radiologic signs on CXR include interposed lung between the aorta and pulmonary artery (AP window), lung between the heart and diaphragm, lung between the right atrium and right ventricular outflow tract and prominent pulmonary vasculature if a shunt is present (possible but unproven in this case). CT may show continuity of the pericardial space with the pleural cavity. Patients may present with palpitations, tachycardia, dyspnea, syncope and intermittent chest pain. Chest pain occurs secondary to torsion of the great vessels and pressure on the coronary arteries lying at the rim of the defect. EKG findings may include right axis deviation and right bundle branch block. If the patient has suffered a pneumothorax, a pneumopericardium will occur. If symptoms dictate or severe congenital defects are present, surgical closure of the pericardium with a pleural flap or resection of the pericardium may be performed.

Miller SM. Cardiac Radiology, The Requisites Series. 1996, Mosby; St. Louis, MO. Dahnert, Wolfgang, Radiology Review Manual. Lippincott Williams and Wilkins, Philadelphia, 2000.

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