http://www.appliedradiology.com RSS Feed on Applied Radiologyhttp://www.appliedradiology.com//Issues/2002/10/Supplements/Restenosis--An-Update.aspxWith more than 1 million percutaneous interventions performed each year in the United States alone, the scope of the vexing problem of restenosis is staggering. To date, the development and clinical application of intracoronary stents has had the single greatest impact on the prevention of restenosis. Bare metal stents effectively prevent remodeling but are unable to counteract neointimal proliferation. Elucidation of downstream molecular events responsible for restenosis has made it easier to rationally select from potential therapeutic options. Recent attention has turned toward the development of novel systems for local drug delivery; drug-coated stents represent the foremost innovation in this area. The marriage of stenting and antiproliferative agents has the potential to eradicate restenosis. Although it does not seem that drug-eluting stents are the cure for restenosis, they do represent the next major advancement.Monday, 03 Mar 2003 16:54:50 GMT