http://www.appliedradiology.com RSS Feed on Applied Radiologyhttp://www.appliedradiology.com//Issues/2001/08/Supplements/Myocardial-Perfusion-Imaging-with-MR-Contrast-Agents.aspxIn 1979, I performed my first magnetic resonance (MR) myocardial perfusion study in canine. At that time, we used manganese chloride given as a bolus and we didn't have to sacrifice the animal at the end of the study. We got very high quality perfusion images and it has been my desire ever since to duplicate that quality clinically. We haven't gotten there yet. Manganese (MnCl2) is an agent like Thallium-201 (201TlCl); it gets into the myocardium, peaks, and very slowly leaks out. It's an intracellular agent, and there are paramagnetic intracellular agents now under development. For myocardial perfusion imaging, we have used two extra-cellular fluid space contrast agents, ProHance® (gadoteridol) or Magnevist® (gadopentate dimeglumine). This presentation will discuss our experience with these agents in a series of about 400 to 500 patients.Thursday, 17 Jan 2002 00:24:53 GMT