http://www.appliedradiology.com RSS Feed on Applied Radiologyhttp://www.appliedradiology.com//Issues/2010/12/Cases/Aceruloplasminemia.aspx<p>A 63-year-old white female presented with a 5 year history of progressive dementia, ataxia, and difficulty swallowing. The patient also had diabetes mellitus. Neuropsychiatric evaluation revealed ataxic gait, marked psychomotor slowing and severe dementia. Laboratory analysis revealed low serum iron (17 mg/dL), high serum ferritin (1343 µg/mL), low serum transferrin saturation (6%), undetectable serum ceruloplasmin (&lt;4.0), normal serum transferrin receptor concentration (25 µmol/L), normal 24 hour urine copper excretion (0.6 µg/dL), high serum HbA1c (7.5), low hemoglobin (10.7). Magnetic resonance imaging (MRI) of the head was performed (Figure 1). </p>Friday, 17 Dec 2010 16:35:20 GMT