Study: Pulmonary Artery Thrombosis a Complication of Radiation Therapy

By News Release

The imaging findings of in situ pulmonary artery thrombosis (PAT) associated with radiation therapy (RT) are different from those of acute pulmonary emboli and do not appear to embolize, according to a recent article in ARRS’ American Journal of Roentgenology (AJR).1 Due to the differences in clinical prognosis and subsequent management strategies, in situ PAT associated with RT—which to the authors' knowledge has not previously been described in the literature—must be distinguished from pulmonary embolism.

Searching the radiology database of a large teaching hospital to identify patients who had PAT develop after receiving RT, first author Jitesh Ahuja from the thoracic imaging department at the University of Texas’ MD Anderson Cancer Center recorded the PAT’s CT characteristics: number, location, appearance of filling defects, as well as the presence of associated lung fibrosis. The terminology (in situ thrombosis vs acute or chronic pulmonary embolism) used to describe PAT, the time between completion of RT and development of PAT, the size change of PAT, and any observation of new thrombi and emboli on follow-up imaging were also recorded.

With a study population consisting of 27 patients (19 men and eight women) at a mean age of 71 (range, 54–90 years), the primary malignancy was lung cancer in 22 patients (81%) and mesothelioma in five patients (19%). Whereas most PATs were solitary (93%) and nonocclusive (96%) and formed an obtuse angle to the vessel wall (89%), all PATs were eccentric within the involved pulmonary artery and located within the RT volume. The time from completion of RT to initial diagnosis of PAT on CT ranged from 53 to 2,522 days (mean, 675 days). In all patients, CT findings of radiation-induced lung fibrosis were present in the lung supplied by the affected pulmonary artery.

68-Year-Old Man With Lung Cancer in Left Lower Lobe Treated With RT. A, Axial CT scan shows RT plan. Absolute = absolute dose of RT, Iso = isocenter. B, CT scan obtained 1 month after RT does not show pulmonary artery thrombosis. C, CT scan obtained 32 months after RT shows eccentric nonocclusive filling defect (arrow) in left interlobar pulmonary artery identified within RT volume. Patient was not treated with anticoagulants. D, Follow-up CT scan obtained 45 months after RT shows increase in size of thrombus (arrow). E, PET/CT image obtained within 1 month of follow-up CT scan in C did not reveal FDG uptake within region of filling defect, suggesting bland thrombus instead of tumor thrombus or recurrence. F, CT scan in lung window shows radiation fibrosis (arrow) in left lung.

“On follow-up imaging, none of the patients were observed to have filling defects develop in other parts of the pulmonary artery, which would have suggested embolization,” Ahuja et al. added.

Acknowledging that RT is a “key choice” in multimodality treatment of intrathoracic malignancies, the authors noted that RT-associated cardiovascular complications remain the leading non–cancer-related cause of morbidity and mortality among cancer survivors. “Radiologist awareness of PAT can facilitate accurate diagnosis and impact management,” they concluded.

REFERENCE

1. Ahuja J, Shroff GS, Benveniste MF et al. In situ pulmonary artery thrombosis: unrecognized complication of radiation therapy. Am J Roentgenol; 2020;1-6. https://www.ajronline.org/doi/abs/10.2214/AJR.19.22741

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Study: Pulmonary Artery Thrombosis a Complication of Radiation Therapy.  Appl Radiol. 

By News Release| October 12, 2020

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