Traumatic neuroma of the breast after mastectomy

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A 73-year-old asymptomatic woman presented to our breast imaging center for screening mammography. Her past medical history was significant for invasive ductal carcinoma of the left breast 16 years prior that was treated with modified radical mastectomy, includ ing removal of 17 axillary lymph nodes all negative for metastasis, followed by Tamoxifen therapy for five years. At our center, we routinely obtain images of residual tissue at mastectomy sites when it can be achieved comfortably, and a bilateral mammogram was thus performed for this patient.


The mediolateral oblique mammogram view of the residual tissue at the left mastectomy site showed a small, equal density oval mass with circumscribed borders (Figure 1). The mass was located at the lateral aspect of the mastectomy site and was not visible on the craniocaudal view. This finding was new when compared with prior mammograms dating 10 years back, and the patient was recalled for further imaging evaluation. Ultrasound demonstrated a 7 mm hypoechoic, oval mass with parallel orientation and circumscribed margins that tapered to a point at one end. There were no posterior acoustic features, and no blood flow was seen with color Doppler evaluation (Figure 2). The mass was noted to be located deep to the lateral aspect of the mastectomy scar visible on the overlying skin. The mass was not palpable and the patient reported no pain in this area. Despite the benign imaging features, an ultrasound-guided core needle biopsy of the mass was performed because it was a new finding in a patient with history of ipsilateral breast cancer. Pathology revealed segments of hyperplastic peripheral nerve consistent with traumatic neuroma.


Benign traumatic neuroma of the breast


Traumatic neuromas that form at the end of a transected nerve are sub-classified as terminal neuromas and may occur following any type of trauma, classically in the setting of limb amputation, but also with a variety of other surgical procedures. They are not true neoplasms, but rather a hyperplastic response of the proximal end of a disrupted nerve in an attempt to reconnect with its distal portion.1 This process is reflected in the typical pathology findings of haphazardly arranged tangles of variably sized regenerating nerve twigs, as well as axons ensheathed by Schwann cells surrounded by perineurium (Figure 3).2

The diagnosis of traumatic neuroma following breast cancer surgery is a rare phenomenon, first described in 2000 with only 18 cases reported since that time.3-10 Traumatic neuromas of the breast occur between 2-22 years after mastectomy (average 10.3 years), and range from 2-10 mm in size.3,4 They may develop in various anatomic locations, but most commonly in the upper outer quadrant of the mastectomy site or the axilla, often in close proximity to the surgical scar. In fact, traumatic neuromas are often detected on physical examination as palpable nodules in a mastectomy scar.5 Regardless of location, most traumatic neuromas of the breast are palpable, although infrequently painful. However, there are several reports of exquisite pain during needle biopsy of traumatic neuromas.3,6

When not detected by palpation, traumatic neuromas of the breast may be discovered incidentally by ultrasound, where they almost uniformly appear as circumscribed, homogeneous, hypoechoic oval masses without vascularity at color Doppler examination. About half of the time, ultrasound shows fusiform tapering of one end of the mass, which has been described as “bulbous end” morphology or the “tail sign.”3,6,7 Of the five reported traumatic neuromas that were also investigated with MRI, only three were visible by MRI where they were T-1 isointense, T-2 variable, and showed benign persistent (Type 1) enhancement.3 There is a single report of a traumatic neuroma evaluated by PET-CT, where it showed no uptake of fluorodeoxyglucose.8 None of the previously reported traumatic neuromas were detected or otherwise visualized by mammography. Because traumatic neuromas of the breast occur in women with a history of breast cancer, they must be differentiated from recurrent breast cancer or metastatic lymph node, and biopsy is therefore always indicated.

The case of traumatic neuroma of the breast that we present is similar to those previously reported in that it occurred post-mastectomy in the vicinity of the surgical scar. Although there was a significant interval of 16 years from the time of surgery to diagnosis of the traumatic neuroma, this is within the reported 2-22 year time frame. Reported symptomatology is variable, and our patient was totally asymptomatic, with no palpable lump or pain, and no pain at the time of core needle biopsy. A unique feature of our case is that the traumatic neuroma presented as a new mass on a screening mammogram, which may be related to our protocol of routinely imaging residual tissue at mastectomy sites when feasible. We observed the classic imaging features at ultrasound of a circumscribed, hypoechoic, nonvascular oval mass, including “tail sign” tapering of the mass to a point. These benign features might have normally resulted in a BI-RADS 3 designation with recommendation for short-term follow-up ultrasound in 6 months. However, the clinical scenario of a new mass at the site of previous mastectomy necessitated a biopsy to obtain a definitive benign diagnosis in this patient with the potential for recurrent breast cancer.

Biopsy-proven traumatic neuromas require no further management unless they are painful, in which case injection of a long-acting anesthetic and steroid may be successful. Surgical excision may be considered in the setting of persistent pain, although this approach has not been reported for the management of traumatic neuromas of the breast.3


Traumatic neuroma of the breast occurs rarely after mastectomy. It is a benign hyperplastic response of a transected nerve, often presenting as a palpable nodule in or near the surgical scar, and is also frequently painful. It is typically and most reliably evaluated with ultrasound, which almost always shows a small, circumscribed, hypoechoic, nonvascular, oval mass. Tapering at one end of the mass, the “tail sign,” is evident by ultrasound in about 50 percent of cases. While these features may suggest a diagnosis of traumatic neuroma, biopsy remains necessary to exclude the possibility of recurrent breast cancer.


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Fitzpatrick KA, Borders MH, MacKerricher WS, Bracamonte ER.  Traumatic neuroma of the breast after mastectomy.  Appl Radiol.  2017;46(6):26-28.

About the Author

Kimberly A. Fitzpatrick, MD; Marisa H. Borders, MD; Wendy S. MacKerricher, MD; and Erika R. Bracamonte, MD

Kimberly A. Fitzpatrick, MD; Marisa H. Borders, MD; Wendy S. MacKerricher, MD; and Erika R. Bracamonte, MD

Prepared by Drs. Fitzpatrick and Borders while serving as Assistant Professors of Medical Imaging at The University of Arizona College of Medicine, as well as Co-Medical Directors of the Banner University Breast Imaging Center, Banner University Medical Center; by Dr. MacKerricher while a Resident in the Department of Pathology at The University of Arizona College of Medicine; and by Dr. Bracamonte while serving as an Associate Professor of Pathology at The University of Arizona College of Medicine in Tucson, AZ, as well as Director of Anatomic and Surgical Pathology at Banner University Medical Center in Tucson, AZ.

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