New Portable PET Scanner Enhances Real-Time Imaging for Interventional Use

A cutting-edge portable PET scanner has been introduced, bringing the advantages of real-time molecular imaging directly to bedside interventional procedures. Presented at the Society of Nuclear Medicine and Molecular Imaging 2026 Annual Meeting, this innovative point-of-care device is capable of imaging any organ with precision, providing valuable guidance for biopsies, tumor ablations, and other interventional procedures within hospital settings.

Traditionally, interventional radiology has depended on anatomical imaging methods like ultrasound, X-ray, fluoroscopy, and CT scans for procedure guidance. However, studies indicate that using a dedicated PET/CT system could enhance accuracy in such procedures. Unfortunately, the high cost of PET/CT systems limits their availability in most healthcare facilities.

Addressing this gap, a team from Washington University in St. Louis, led by Yuan-Chuan Tai, PhD, has developed a mobile PET system with a robotic arm. This system allows the placement of detector panels in various positions to target any organ, thus ensuring comprehensive molecular imaging capabilities.

The study evaluated the feasibility of dynamic PET scanning and real-time image updates using this portable system. In experiments, a phantom with radiotracer-filled rods was scanned with the detector panels set at six predetermined locations. Initial image reconstruction involved five iterations at the first position. Subsequent updates used a single iteration as data from each new location was processed. Given that data acquisition outpaced reconstruction, images were continuously refined as new information became available.

The research revealed that the image quality achieved with this portable system’s real-time framework was comparable to that produced by traditional PET systems. Clearly identifiable structures appeared after a few positional adjustments, suggesting the possibility of halting the scan once sufficient imaging data is obtained. Alternatively, further positions and iterations could improve image quality.

"This portable PET system promotes interactive and adaptable imaging workflows at the bedside, representing a significant shift in the deployment of molecular imaging," said Xiyan Li, a graduate researcher at Washington University.

The initial study utilized a benchtop prototype, and efforts are underway to develop a version suitable for human tests, anticipated to start in 2027. This advancement holds promise for expanding the reach of precise molecular imaging in clinical environments, potentially transforming how interventional procedures are conducted.